Hi Mruniverce,

The biggest concern is whether your Tele has big enough cavities to fit a humbucker. If your Tele had humbuckers to start, then switching them out should be just fine, but I'm guessing your guitar doesn't, since you're asking this question.

You have to first make sure the cavities are big enough to fit a humbucker, and then once they are, you'll have to get a new pickguard that would also fit humbuckers.

Once you figure out that, you can't go wrong tossing in some Seymour Duncan pickups, or perhaps some EMGs.