Yes,

size matters.

I have thick hands and fingers, and I started out with a wonderful Taylor acoustic that happened to have a 1-11/16 neck. All of my electric(s) had 1-5/8 "nuts."

Little did I know.

When I played an acoustic that felt better, I found out that it had a 1-3/4 neck. From that point on, there was no turning back. Bought a Martin 000-15SM (wonderful guitar) and put the Taylor up for sale. I always buy used.

In regard to the electric, I sold my dream guitar, a Fender Custom Shop Telecaster Relic (made a bit of money on it), and bought a fully loaded '62 Fender AVRI Stratocaster body (only), then ordered a custom-made neck with 1-3/4 nut for it from Warmoth.

The switch to wider string spacing (not just the nut -- i.e., 2015 Gibson Les Paul!) has helped me a great deal to play cleaner.