I have the POD HD500X and what I do on live gigs is putting the xlr connectors directly to the PA system and the regular jack out to my amp, a Fender 410 hotrod Deville MK I so the audience gets the real POD sound in stereo and I can still hear myself play very good to without having to mix my signal to much in the monitors and clutter that sound up.

For home use I have the Line 6 Amplifi 75 which is nice to since I can play backing tracks from my smartphone through bluetooth and play along with the guitar ( and mix ) with any sound like the POD,

regards Herman